Adiponectin and its receptors are involved in hypertensive vascular injury

نویسندگان

  • Ruimin Guo
  • Min Han
  • Juan Song
  • Jun Liu
  • Yanni Sun
چکیده

Adipocyte-derived adiponectin (APN) is involved in the protection against cardiovascular disease, but the endogenous APN and its receptor expression in the perivascular adipocytes and their role in hypertensive vascular injury remain unclear. The present study aimed to detect endogenous APN and its receptor expression and their protective effects against hypertensive vascular injury. APN was mainly expressed in the perivascular adipocytes, while its receptors AdipoR1 and AdipoR2 were ubiquitously expressed in the blood vessels. Angiotensin II (Ang II)‑induced hypertension resulted in a significant decrease of APN and AdipoR1 and AdipoR2 in the perivascular adipocytes and vascular cells. The migration assay used demonstrated that APN attenuated Ang II‑induced vascular smooth muscle cells migration and p38 phosphorylation Furthermore, the in vivo study demonstrated that APN receptor agonist AdipoRon attenuated Ang II‑induced hypertensive vascular hypertrophy and fibrosis. Taken together, the present study indicated that perivascular adipocytes‑derived APN attenuated hypertensive vascular injury possibly via its receptor‑mediated inhibition of p38 signaling pathway.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

O-13: Gene Expression Pattern of Adiponectin and Adiponectin Receptors in Bovine Dominant and Non-Dominant Follicles

Background: Recent studies have revealed that adiponectin, a novel adipocytokine, and its two receptors (AdipoR1 and AdipoR2) are involved in regulation of ovarian function in various farm animal species. The aim of this study was to investigate the gene expression pattern of Adiponectin and its receptors in ovarian cells of dominant (DFs) and non- dominant follicles (NDFs) in the bovine. Mater...

متن کامل

Different Stages of Platelet Adhesion to the Site of Vascular Injury

Platelet activation and adhesion to the site of vascular injury is a dynamic process comprising reversible and irreversible phases. Platelet adhesion typically occurs in a multi-step process similar to the selectin/integrin-mediated adhesion of neutrophils. This phenomenon is highly regulated and influenced by the cross-talk between platelets and injured endothelium. This cross-talk involves a ...

متن کامل

Correlation of Adiponectin mRNA Abundance and Its Receptors with Quantitative Parameters of Sperm Motility in Rams

Objective Adiponectin and its receptors (AdipoR1 and AdipoR2), known as adiponectin system, have some proven roles in the fat and glucose metabolisms. Several studies have shown that adiponectin can be considered as a candidate in linking metabolism to testicular function. In this regard, we evaluated the correlation between sperm mRNA abundance of adiponectin and its receptors, with sperm moti...

متن کامل

Effects of interventions on adiponectin and adiponectin receptors

Adiponectin secreted from adipose tissue binds to two distinct adiponectin receptors (AdipoR1 and AdipoR2) identified and exerts its anti-diabetic effects in insulin-sensitive organs including liver, skeletal muscle and adipose tissue as well as amelioration of vascular dysfunction in the various vasculatures. A number of experimental and clinical observations have demonstrated that circulating...

متن کامل

اثر آدیپونکتین بر بیان ژن استئونکتین در رده سلولی عضله صاف رگ

Background and purpose: Atherosclerosis is a major cause of death in adults in most countries. Many studies have focused on the protective role and anti-inflammatory properties of adiponectin but its role in calcification has been less studied. Studies that could determine the causes and mechanisms of calcification could be of great value. The aim of this study was to investigate the effects...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 17  شماره 

صفحات  -

تاریخ انتشار 2018